How Biologic Medicines Are Made | How It’s Made


♪♪ Narrator:
BIOLOGIC MEDICINES ARE PROTEINS PRODUCED INSIDE LIVING CELLS, WHICH ARE MINI FACTORIES GENERATING THE
GENETICALLY-ENGINEERED PROTEIN TREATMENTS. IT’S A DIFFERENT APPROACH
FROM TRADITIONAL DRUGS, WHICH ARE MANUFACTURED
USING CHEMICAL SYNTHESIS. BIOLOGICS OFFER HOPE WHERE
OTHER THERAPIES HAVE FAILED. TO MASS PRODUCE
THESE BIOLOGIC MEDICINES, SCIENTISTS USE THE
MOLECULAR MACHINERY INSIDE LIVING CELLS. THE PROCESS STARTS WITH THE INSERTION OF
GENETIC MATERIAL INTO CHINESE HAMSTER
OVARIAN CELLS. THEY’RE KNOWN AS C.H.O. CELLS. THEY KEEP THEM FROZEN
IN LIQUID NITROGEN UNTIL THE NEXT STEP. IN THE SEED LAB, A TECHNICIAN THAWS THE CELLS
IN WARM WATER. HE TRANSFERS THEM
TO A GLASS FLASK THAT CONTAINS GROWTH MEDIA. THE GROWTH MEDIA IS COMPRISED OF
HUNDREDS OF NUTRIENTS, INCLUDING VITAMINS AND MINERALS. IT’S A RECIPE
TO HELP THE CELLS MULTIPLY. A WORKER TRANSFERS THE FLASK
THAT CONTAINS THE CELLS TO THE PRODUCTION SIDE
OF THE PLANT. THE TEAM INJECTS THE MIXTURE INTO A FIVE-GALLON CAPACITY
BIOREACTOR. INSIDE, A PROPELLER
AGITATES THE MIXTURE TO STIMULATE GROWTH. OVER A THREE-WEEK PERIOD, THE NUMBER OF CELLS
INCREASES EXPONENTIALLY. EACH NEW CELL
IS PROGRAMMED TO PRODUCE THE TARGET BIOLOGIC PROTEIN. NEXT, A TECHNICIAN MEASURES
SALTS AND OTHER DRY INGREDIENTS. HE’S PREPARING A RECIPE
FOR PURIFYING THE PROTEIN LIQUID ONCE IT’S BEEN SEPARATED
FROM THE CELLS. HE LABELS THE BAG AND RECORDS THE INFORMATION
SEPARATELY, AS REQUIRED BY
GOVERNMENT REGULATIONS. HE ADDS THE INGREDIENTS
TO PURIFIED WATER IN A MIXING TANK. AN AUTOMATED SYSTEM
KEEPS TABS ON THE CONDITION OF THE PURIFICATION SOLUTION. AFTER SEPARATING
CELLULAR MATERIAL FROM THE PROTEIN MIXTURE, THE TEAM PUMPS IT THROUGH
STEEL-AND-GLASS COLUMNS. HERE, THE PURIFICATION SOLUTION
WORKS WITH RESIN BEADS TO SEPARATE THE PROTEIN
FROM THE IMPURITIES. FINALLY, THIS TECHNICIAN
TAKES A SAMPLE AND CONDUCTS A TEST TO ENSURE
THE MEDICINE IS STERILE. GROWN IN LIVING CELLS, THESE BIOLOGIC MEDICINES
ARE NOW ON THEIR WAY TO POTENTIALLY MAKING
A DIFFERENCE IN PEOPLE LIVES.

21 thoughts on “How Biologic Medicines Are Made | How It’s Made

  1. Practical knowledge.. Self practical training done is must…. Be real be practical….. Sports games fun enjoyment love sex lust etc are must always.. Self work self interests self style are must always…

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