Origin of the Fasting Mimicking Diet & the path to broader clinical acceptance | Valter Longo

[Rhonda]: So, you were talking about this
fasting-mimicking diet in humans this clinical study in humans that you have a pilot trial
that you had done in humans, where you’re… So, with the mouse studies into fasting, and
their autophagy in the regenerating of the stem cells, and, you know, that stuff’s all
very exciting and has relevance for, you know, for cancer, and for aging, in general. But how can you translate like a 48-hour fast
to humans, and is that, sort of, why you’ve come up with this fasting-mimicking diet because
the amount of time would have to be like a week, or five days, or something that seems
a lot more difficult for humans to do? [Valter]: Yeah. So, it’s not just about difficulty, it’s also
about safety. And so, when we first started with the fasting
in cancer patients, basically the patients didn’t want to do it, and the doctors didn’t
want to do it, so it’s really a struggle. And it took us forever here at the Norris
Cancer Center, our own University, to get 18 patients to go through it, it took us like
five or six years. So, it was very difficult. And then, we started asking people, “What
if we give you a fasting-mimicking diet?” And we started asking doctors, “What if we
give patients a box, and it has all the foods that they need?” So, it’s more of a medicine, right? You just hand over to the patient a medicine. And then, everything turned around, so people
were much more likely to do it, they felt like… [Rhonda]: It’s more compliance. [Valter]: …psychologically, we give them
something, they also, of course, they’re eating almost normal…I mean, normally in the sense
at the right times, they’re not eating normally, but obviously, the diet is very different
than the normal diet. And the doctors felt so good about it. So, I think, it was really important to get
to get the fasting-mimicking diet going, and, you know, so now we have a number of trials
in cancer patient, in diabetes patients. Soon enough, we’ll start with…well, we finished
one multiple sclerosis, and so, now, we’re ready to start talking to the FDA about moving
to the next level. I think people are underestimating the power
of this, and there’s good and bad, I guess, but I think that it’s got a real potential
as we’re seeing now that we’re talking to doctors. And now we’re seeing a lot of doctors, cardiologists,
and endocrinologists, gynecologists prescribing it, right? Or recommending, and they’re not prescribing,
it’s not a drug. But they’re recommending it to a patient,
and it’s been great, you know. And now we have a couple of hundred doctors
that we’re been talking to see this group of people changed from this drug-centered
mentality to, maybe there are things that we didn’t realize could be very powerful,
and much more able to, again, let the body fix itself. And so, I would not be surprised if in 10
years, worldwide, these type of interventions are gonna be standard in the doctor’s office.

2 thoughts on “Origin of the Fasting Mimicking Diet & the path to broader clinical acceptance | Valter Longo

  1. Watch the full episode:

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  2. Breaking up the individual interviews into this smaller format with clips has made rewatching each interview significantly more digestible and easier in regards to time management! Thank you so much!

    And please go back on the JRE podcast soon with more new research! I love your podcast and the medical focus but the everyday questions that Joe can hit you with has made for amazing interviews

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